Plumbagin Causes Abortive Effects When Fed to Pregnant Sprague Dawley Rats during the Late Gestation Period

Developmental toxicity by exposure to bisphenol A diglycidyl ether during gestation and lactation period in Sprague-Dawley male rats.

OBJECTIVES Bisphenol A diglycidyl ether (BADGE) is the major component in commercial liquid epoxy resins, which are manufactured by co-reacting bisphenol A with epichlorohydrin. This study was performed to show the developmental effects of prenatal and postnatal exposures to BADGE in male rat offspring. METHODS Mated female rats were divided into four groups, each containing 12 rats. The dosi...

Effects of genistein on male sprague dawley rats reproductive development

Genistein (Gen), is commonly consumed phytoestrogen among Asian and known to exert weak estrogenic effects. To account for potential reproductive effects in male rats, Control, Gen1, Gen10, Gen100 mg/kg body weight and Estradiol were administered to gestational day 10 (GD10) female Sprague Dawley for 5 weeks. At postnatal day, P50, the rats were sacrificed. Blood was taken and reproductive tiss...

Histopathological Effects of 2,4-Dichlorophenoxyacetic Acid on Sprague-Dawley Rats

This study investigated the toxic effects of 2,4-dichlorophenoxyacetic acid on male Sprague-Dawley rats. In which, 30 rats were divided into three even groups. First group received orally normal saline (3 ml/kg b.w.) and kept as normal control in parallel to treated groups (5 rats each), second group received orally 2,4-dichlorophenoxyacetic acid (30 mg/kg b.w.) for 2 months and third group rec...

The Effects of Aerobic Exercise in Sprague Dawley pregnant Rats on vascular BCL-2,BAX AND eNOS Gene Expression in adult male offspring

  Background: One of the most growing diseases is the onset of atherosclerosis which can be started from a fetal age. As a result, the intrauterine environment plays a role at risk of spreading this disease. Changes in vascular function considered to be as an indicator for vascular disease. Effective factors on vascular function are enzyme eNOS and apoptotic regulator factors included BCL-2 an...

Repeatedly heated cooking oils alter platelet functions in cholesterol fed Sprague dawley rats